Research Articles
The Invisible Assault: How Everyday Chemicals Damage Your DNA
Explore how environmental chemicals like acetaldehyde, acrolein, aristolochic acids, and vinyl chloride damage DNA and how cellular repair mechanisms protect us from cancer.
The Silent Sabotage: How Hexavalent Chromium Cripples Our Cells' Repair Mechanisms
Discover how hexavalent chromium simultaneously damages DNA and suppresses cellular repair mechanisms, leading to increased cancer risk.
H2AX: The Genome's Guardian and Its Crucial Role in Fighting Cancer
Explore H2AX, the specialized histone protein that serves as DNA's security system, detecting double-strand breaks and recruiting repair crews to prevent cancer.
The DNA Repair Artists: How Specialized Enzymes Copy Damaged DNA
Exploring how specialized DNA polymerases like Pol ν and Pol θ perform translesion synthesis to bypass DNA-protein and DNA-DNA cross-links, maintaining genome stability.
The Hidden Guardian: How a Cell Death Protein Doubles as DNA Repair Superhero
Discover how Bax protein, traditionally known for cell death, plays a crucial role in DNA repair after UV irradiation and its implications for cancer biology.
The Double-Edged Sword of Stem Cells: How Lab Life Can Lead to Genetic Chaos
Exploring how long-term mesenchymal stem cell culture affects genetic stability through ATM-dependent DNA repair mechanisms
The Lung's Dirty Secret: How Your Airway Guardians Use 'Genetic Duct Tape' to Survive
Discover how lung basal stem cells use error-prone DNA repair to survive environmental toxins - a fascinating trade-off between survival and genetic perfection.
The Cancer Cell's Double-Edged Sword: How a Common Flaw Makes Tumors Vulnerable
Discover how the loss of TGFβ signaling creates a critical vulnerability in cancer cells by forcing them to use error-prone DNA repair, making them more sensitive to therapies.
The Cerebellum's Hidden Battle: When Two DNA Repairmen Fail
Discover how the loss of Atm and Polβ DNA repair proteins in the cerebellum leads to neurological disorders and uncover the surprising link between DNA damage and gene regulation.
The DNA Guardian: How SIRT1 Fights Damage to Keep Your Cells Alive
Discover how SIRT1, the master regulator protein, protects your DNA from damage and promotes cellular survival through sophisticated repair mechanisms.